学術著書・論文
学術著書・論文は、ペンネ―ムの才園哲人ではなく、本名の好田 肇で執筆しています。
主な研究論文
著書
1.Genetics of Industrial Microorganisms (Academic Press)
Amino Acid Fermentation using Regulatory Mutants of Corynebacterium glutamicum.
pp.131〜449('79)
K.Nakayama, K.Araki, H,hagino, H.Kase and H.Yoshida
2.アミノ酸発酵 (学会出版センター)
アルギニン・シトルリン・オルニチン発酵 pp.243〜263('86)
好田 肇
2.biotechnology of amino acid production (KODANNSHA/ELSEVIER)
Arginine, citrulline and Ornithine. Pp.131〜 143('86)
H.Yoshida
3.最新 微生物ハンドブック (サイエンスフォーラム)
ハイブリドーマ pp.210〜236('86)
高津聖志、好田 肇
4.抗ーヒト腫瘍モノクローナル抗体の効率的作製法
単著 (アイピーシー出版)('89)
総 説
1.アルギニン・シトルリン・オルニチン発酵
単著 発酵と工業,40, 541 〜 551(' 82)
2.モノクローナル抗体を用いるがん治療の現状
単著 化学と工業,36, 88〜90('83)
3.ハイブリドーマ技術の医学への応用
1.ハイブリドーマの作製法とその応用
単著 日医誌,8月1日号('83)
2.モノクローナル抗体による癌の診断と治療
単著 日医誌,9月1日号('83)
4.動物細胞の融合とその応用
単著 第9回技術セミナー テキスト pp.24 〜 27('86)
学術報文
1.Fermentative Production of L-Arginine.
Amino Acid and Nucleic Acid, No.25, 141 〜149('72) K.Nakayama and H.Yoshida
2.Fermentative Production of L-Arginine.
Agr.Biol.Chem., 36, 1675〜1684('72)
K.Nakayama and H.Yoshida
3.L-Tyrosine Production by Polyauxotrophic Mutants of Corynebacterium
glutamicum .
Agr.Biol.Chem., 37, 2001〜2005('73)
H.Hagino, H.Yoshida, F.Kato, K.Araki, R.Katsumata and K.Nakayama
4.Production of 3,4-Dihydrophenyl-L-alanine (L-DOPA) and its Derivertives
by Vibrio tyrosinaricus.
Agr.Biol.Chem., 37, 2121〜2126('73)
H.Yoshida, Y.Tanaka and K.Nakayama
5.数種細菌のL‐セリンアナログ抵抗性変異株によるL‐セリンの生成およびLーセリン生成
におよぼすスレオニンとホモセリンの効果
農化誌.48, 201 〜208('74)
好田 肇、中山 清
6.Production of 3,4-Dihydrophenyl-L-alanine (L-DOPA) by Pseudomonas
melanogenum.
Agr.Biol.Chem., 38, 455 〜462('74)
H.Yoshida, Y.Tanaka and K.Nakayama
7.Properties of Tyrosinase from Pseudomonas melanogenum.
Agr.Biol.Chem., 38, 627 〜632('74)
H.Yoshida, Y.Tanaka and K.Nakayama
8.Production of 3,4-Dihydrophenyl-L-alanine (L-DOPA)by Mutants of
Pseudomonas melanogenum.
Agr.Biol.Chem., 38, 633 〜639('74)
H.Yoshida, Y.Tanaka and K.Nakayama
9.Cysteine Formation from Methionine in Pseudomonas melanogenum and
Mechanisum of Methionine-inhibition of L-DOPA Production by the Bacteria.
Agr.Biol.Chem., 38, 873 〜874('74)
H.Yoshida, T.Oka, Y.Tanaka and K.Nakayama
10.Microbacterium ammoniaphilumのアルギニンハイドロキサメイト抵抗性変異株による
アラニンの生産
農化誌.49, 527 〜532('75)
好田 肇、中山 清
11.N-Acetylornithine-δ-aminotransferase-deficient and N-acetyl-
glutamokinase deficient Arginine Auxotrophs of Corynebacterium
glutamicum .
Agr.Biol.Chem., 44, 361 〜365('79)
H.Yoshida, K.Araki and K.Nakayama
12.N-Acetylglutamate-acetylornithine Acetyltransferase-Deficient Arginine
Auxotroph of Corynebacterium glutamicum .
Agr.Biol.Chem., 44, 1899〜1979('79)
H.Yoshida, K.Araki and K.Nakayama
13.Mechanisum of L-Arginine Production by L-Arginine-producing Mutants of
Corynebacterium glutamicum .
Agr.Biol.Chem., 43, 105 〜111('79)
H.Yoshida, K.Araki and K.Nakayama
14.L-Arginine Production by Arginine analog-resistant Mutants of
Microorganisms.
Agr.Biol.Chem., 45, 959 〜963('81)
H.Yoshida, K.Araki and K.Nakayama
15.Microbial Production of Abscisic Acid with Cercospora rosicola.
1.Stimulation of Abscisic Acid Accumulation by Plant Extracts.
Biotechnology Letters, 5, 55〜58('83)
K.Takayama, H.Yoshida, K.Araki and K.Nakayama
16.Microbial Production of Abscisic Acid with Cercospora rosicola.
2.Effect of pH Control and Medium Composition.
Biotechnology Letters, 5, 59〜62('83)
K.Takayama, H.Yoshida, K.Araki and K.Nakayama
17.抗−ヒト肺癌モノクローナル抗体(KM-32)によって検出される肺癌患者血清中のKA-32
第5回腫瘍マーカー研究会記録,pp.63 〜65('85)
矢野 況、宮国泰夫、平田清司、青山昭徳、仁井谷久暘、河内重人、弦間昭 彦、長谷川浩一、坪井栄孝、設楽研也、花井陳雄、好田 肇
18.抗−ヒト肺癌モノクローナル抗体(KM-93)の作製と肺癌臨床診断への応用
第5回腫瘍マーカー研究会記録,pp.66 〜69('85)
設楽研也、花井陳雄、好田 肇、仁井谷久暘、有吉 寛
19.Generation of Monoclonal Antibodies against Human Lung Squamous Cell
Carcinoma and Adenocarcinoma Using Mice Rendered Tolerant to Normal
Human Lung.
Cancer Research, 46, 4438〜4443('86)
N.Hanai, K.Shitara and H.Yoshida
20.Distribution of a Squemous Cell Lung Carcinoma-associated Antigen, KA-32,
in Human Tissues and Sera Defined by Monoclonal Antibody KM-32.
Cancer Research, 46, 5206〜5210('86)
N.Hanai, K.Shitara and H.Yoshida
21.Generation of New Monoclonal Antibody and its Application for
Determination and Purification of Biologically Active Human γ-
Interferon.
HYBRIDOMA, 5, 329〜338('86)
S.Oda, S.Akinaga, A.Kumagai, A.Inoue, N.Nakamizo and H.Yoshida
22.市販のコレラワクチンによるTNF 産生の誘導
医学のあゆみ,140, 981〜982('87)
皆川治重、各務善之、好田 肇、冨田房男、稲川裕行、水野伝一
23.Distribution of Lung Adenocarcinoma-associated Antigens in Human Tissues
and Sera Defined by Monoclonal Antibody KM-52 and KM-9
Cancer Research, 47, 1267〜1272('87)
K.Shitara, N.Hanai and H.Yoshida
24.Expression of the T-cell Receptor γ-Chain Gene Products on the Surface
of Peripheral T cells and T-cell Blasts Generated byAllogeneic Mixed
Lymphocyte Reaction.
Proc.Natl.Acad.Sci.USA, 84, 6536〜6540('87)
K.Maeda, N.Nakanishi, B.L.Rogers, W.G.Haser, K.Shitara, H.Yoshida,
Y.Takagi, A.A.Augustin and S.Tonegawa
25.Monoclonal Antibodies against Synthesized Short Peptides Corresponding to
Human AA Amyloid Protein.
Acta Pathol.Jpn.,37, 1135 〜1142('87)
T.Yokota, T.Ishikawa, M.Takahashi, Y.Yamashita, H.Kawano, Y.Fujinaga,
F.Uchino, N.Hanai, H.Yoshida, S.Honda, M.Sato and N.Matsumoto
26.Generation and Application of Monoclonal Antibodies against Salmon
Somatotropin (Salmon Growth Hormone) and Salmon Prolactin.
Agr.Biol.Chem., 51, 2331〜2335('87)
A.Furuya, M.Ohtomo, T.Inada and H.Yoshida
27.抗−ヒト肺癌モノクローナル抗体(KM-227) の作製と肺癌臨床診断への応用
第6回腫瘍マーカー研究会記録,pp.94 〜96('87)
設楽研也、熊谷安希子、花井陳雄、好田 肇
28.Comparative Studies on Monoclonal Antibodies Raised against Human
Gastric Cancer for Application to Serum Diagnosis of Cancer.
Anticancer Research, 8, 329 〜334('88)
N.Hanai, A.Furuya, K.Shitara, S.Oda and H.Yoshida
29.Production of Lactase by Mutants of Kluyveromyces lactics.
Agr.Biol.Chem., 52, 951 〜955('88)
30.Monoclonal Antibody against Polyglucosan Isolated from the Myocardium of
a Patient with Lafora Disease.
J.Neuropathol.Exp.Neurol.,47, 572 〜577('88)
T.Yokota, T.Ishikawa, H.Yoshida, M.Takahashi, F.Uchino and S.Hamanaka
31.Endogenous Tumor Necrosis Factor Induction with Bordetella pertusis
Vaccine as a Triggering Agent and Its Therapeutic Effect on MM46
Carcinoma-bearing Mice.
Jpn.J.Cancer Res.,79, 384 〜389('88)
H.Minagawa, Y.Kakamu, H.Yoshida, F.Tomita, H.Oshima and D.Mizuno
32.Generation and Application of Monoclonal Antibodies specific for Human
Hemoglobin.
Agr.Biol.Chem., 52, 2837〜2841('88)
H.Yoshida and A.Kusano
33.Generation and Characterization of monoclonal Antibodies to Recombinant
Human Granulocyte-colony stimulating Factor and its Muteins.
Agr.Biol.Chem., 53, 1095〜1101('89)
H.Yoshida and S.Shitara
34.抗−ヒト肺癌モノクローナル抗体(KM-227/432) による肺腺癌の血清診断
第7回腫瘍マーカー研究会記録,pp.223〜225('88)
設楽研也、好田 肇
35.Advantage of Cocktail-Use of Two Anti-tumor Monoclonal Antibodies, KM-93
and KM-231, in Serum Diagnosis of Cancer.
Anticancer Research, 9, 999〜1004('89)
K.Shitara, N.Hanai, A.Furuya, and H.Yoshida
36.Intratumoral induction of tumor necrosis factor by systemic administration of
Bordetella pertusis vaccine.
Br.J.Cancer, 62, 372〜375('90)
H.Minagawa, H.Kobatashi, H.Yoshida, M.Teranishi, A.Morikawa, S.Abe,
H.Oshima and D.Mizuno
37.Detailed Characterization of Reactivities of Anti-Gastric Cancer Monoclonal
Antibodies To Carbohydrate Antigen.
Anticancer Research, 10,1579〜1586('90)
N.Hanai, K.Shitara, A.Furuya, and H.Yoshida, T.Dohi, E.Nudelman,
S.Hakomori and S.Sato
38.Application of Anti-Sialyl Lea Monoclonal Antibody, KM-231, for
Immunotherapy of Cancer.
Anticancer Research, 11,2003〜2014('91)
K.Shitara, N.Hanai, A.Kusano,A.Furuya, and H.Yoshida, K.Wada,
T.Watanabe and S.Sato
39.Development of Anti-Idiotype Monoclonal Antibodies for Sialyl Le-a Antigen.
Anticancer Research, 12,27〜32('92)
A.Furuya, H.Yoshida and N.Hanai
40. Gag-Env 融合蛋白抗原を用いたHTLV−1 抗体測定試薬"デターミナHTLV−1
抗体"の開発 ・・・基礎的性能評価・・・
臨床検査,36,785〜788('92)
森 秀治、竹中浩子、田原亜伊子、三池 彰、佐藤征二、町田容造、
好田 肇、福井正憲
41.Application of Anti Lung Adenocarcinoma Monoclonal Antibody Recognizing
Cytokeratin-like Cytoplasmic Antigen for Tumor Diagnosis.
Anticancer Research, 12,1121〜1130('92)
K.Shitara ,K.Fujiwara, A.Kusano, K.Yamaguchi, H.Yoshida, S.Sato
and N.Hanai
42.Antitumor effect of a novel monoclonal antibody with high binding affinity to
ganglioside GD3.
Cancer Immunology Immunotherapy, 36,260 〜266('93)
S.Otha, A.Honda, Y.Tokutake, H.Yoshida and N.Hanai
43. HCV関連抗原N−14(SGH−N14融合抗原)を用いたC方肝炎診断の基礎的
検討
臨床検査,37,209〜213('93)
守田和樹、森 秀治、福井正憲、杉本整治、好田 肇、長谷川護、
前田栄樹、有馬暉勝
44.Characterization of Monoclonal Antibodies Directed against Human Atrial
Natriuretic Peptide with Different Antigenic Determinant Specificity
KUMAMOTO MEDICAL JOURNAL, 44,(1),1 〜 8('93)
S.Naomi, T.Umeda, T.Iwaoka, T.Sato, K.Hashizume, K.Shitara, K.Yamada,
H.Yoshida and K.Takatsu
45.Detection of a Novel Lung Adenocarcinoma-Associated Serum Antigen
Defined by Two Monoclonal Antibodies,KM432 and KM227
ANTICANCER RES.,13, 579〜586('93)
K.Shitara, N.Hanai and H.Yoshida
46.Production of ubiquinone-10 using bacteria
J.Gen.Appl.Microbiol.,44, 19〜26('98)
H.Yoshida, Y.Kotani, K.Ochiai and K.Araki